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Guayaquil is different, that's true. The coast in and of itself is very different. Guayaquil and Durán are the most gang-invaded zones - but they're not that nice to visit, either. Manta is the "safest" tourist part for now, the whole sierra - Cotacachi, Loja, Cuenca... - is still awesome to travel, same goes for the amazon and galápagos.